iTunes 8.2.1 is on Software Update
This morning Software Update let me know that iTunes 8.2.1 was ready for me, and so I installed it. The update notice said something about syncing with iPhone OS 3.0 devices, but that's already there, so I have a feeling it's either in anticipation of the iPhone OS 3.1 - or they are plugging a hole in the jailbreakers or Palm Pre syncing that they left exposed and wanted to plug.
In any case, it works great for me. Could not be happier.
UPDATE: Holy Cow! I could not have been more on the money: the update is confirmed to break the Palm Pre. This article points out the details, and while I can feel sorry for the Pre, they essentially used undocumented APIs and they got caught at it. Tough break.